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- Title
CALCITONIN GENE-RELATED PEPTIDE AND ENDOTHELIN IN DIGITAL SKIN IN RAYNAUD'S PHENOMENON.
- Authors
Bunker, C. B.; Terenghi, G.; Springall, D. R.; Polak, J. M.; Dowd, Pauline M.
- Abstract
This article studies calcitonin gene-related peptide and endothelin in digital skin. The potent endogenous vasodilator calcitonin gene-related peptide (CGRP) is implicated in the control of peripheral cutaneous blood flow. Qualitative or quantitative digital CGRP mediated dysfunction may contribute to the pathophysiology of Raynaud's phenomenon (RP). The role of the endothelium-derived vasoconstrictor, endothelin in cutaneous microvascular control is not known. The distribution and quantity of CGRP and endothelin IR immunoreactivity in normal digital skin and that of patients with RP has been determined by immunocytochemistry.
- Subjects
CALCITONIN; PEPTIDE hormones; THYROID hormones; HEMODYNAMICS; PATHOLOGICAL physiology; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; DERMATOLOGY
- Publication
British Journal of Dermatology, 1990, Vol 123, Issue 6, p814
- ISSN
0007-0963
- Publication type
Article