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- Title
Normal cellular immunity in Cockayne's syndrome: evidence for the role of defective immunosurveillance in the causation of skin cancer.
- Authors
Norris, P. G.; Hamblin, A.; Cole, J.; Arlett, C. F.; Hawk, J. L. M.
- Abstract
This article reports that there is evidence of defective DNA repair and increased UV-induced fibroblast mutability in both Cockayne's syndrome (CS) and xeroderma pigmentosum (XP), but increased cancer risk occurs only in the latter. XP patients also have defective cell mediated immvinity, but this has not previously been studied in CS. Three girls with CS, diagnosed by appropriate clinical features and by impaired post-UV RNA synthesis, were investigated. Frequency of mutation of circulating lymphocytes to resistance to the lethal action of 6-thioguanine, a measure of somatic cell mutation rate, was assessed using a modified cloning technique.
- Subjects
DNA repair; CANCER patients; BIOCHEMICAL genetics; PRECANCEROUS conditions; LEUCOCYTES; GENETIC engineering; XERODERMA pigmentosum
- Publication
British Journal of Dermatology, 1988, Vol 119, p29
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1988.tb05358.x