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- Title
Influence of elevated liver fat on circulating adipocytokines and insulin resistance in obese Hispanic adolescents.
- Authors
Kim, J. S.; Lê, K.-A.; Mahurkar, S.; Davis, J. N.; Goran, M. I.
- Abstract
Summary Objective We performed this study to examine the metabolic differences arising from higher liver fat accumulation in obese Hispanic adolescents, with a particular focus on circulating levels of adipocytokines and insulin resistance. Methods Forty-one obese Hispanic adolescents (15.3 ± 1.0 years, body mass index percentile: 97.0 ± 3.9) were assessed for: visceral adipose tissue ( VAT), subcutaneous adipose tissue ( SAT) and hepatic fat fraction ( HFF) by magnetic resonance imaging; fasting measures of serum glucose, insulin and adipocytokines; homeostasis model assessment of insulin resistance ( HOMA-IR); and insulin sensitivity ( SI) and the acute insulin response to glucose ( AIR) by intravenous glucose tolerance test. Subjects with normal levels of HFF (below 5%; n = 25) were compared to those with HFF > 5% ( n = 16). Results The two groups differing in HFF were similar for total body fat, VAT and SAT. The group with HFF > 5% had significantly ( P < 0.05) higher interleukin-8 ( IL-8) (6.1 ± 1.6 vs. 3.2 ± 0.4 pg mL−1), NGF (30.2 ± 9.9 vs. 13.9 ± 1.6 pg mL−1), HOMA-IR (8.8 ± 1.1 vs. 5.5 ± 0.5), AIR (1869 ± 206 vs. 1092 ± 165) and a tendency for lower SI (1.2 ± 0.4 vs. 2.1 ± 0.3; P = 0.06), with no significant differences in any of other factors measured. Conclusions These data suggest that elevated liver fat is most closely associated with elevated serum IL-8 and NGF levels as well as increased AIR and HOMA-IR. These elevated factors may play significant roles in the metabolic abnormalities associated with elevated liver fat in obese Hispanics.
- Subjects
FATTY liver; ADIPOKINES; INSULIN resistance; MAGNETIC resonance imaging; ADOLESCENT obesity; BODY mass index; ADIPOSE tissues; GLUCOSE tolerance tests
- Publication
Pediatric Obesity, 2012, Vol 7, Issue 2, p158
- ISSN
2047-6302
- Publication type
Article
- DOI
10.1111/j.2047-6310.2011.00014.x