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- Title
Acyclic Cucurbit[n]urils: Effective Taste Masking Nanocontainers for Cationic Bitter Compounds.
- Authors
Peng, Wen‐Chang; Lei, Zhuo; Lin, Qi‐Han; Wu, Yan; Yang, Jing‐Yu; Wang, Hui; Zhou, Wei; Zhang, Dan‐Wei; Li, Zhan‐Ting; Ma, Da
- Abstract
New acyclic cucurbit[n]urils (ACBs) with eight carboxylate groups were synthesized. These hosts are highly soluble in water, and can form stable inclusion complexes with cationic bitter compounds. ACBs are confirmed to be non‐toxic and biocompatible. Two‐bottle preference (TBP) tests on mice show that all ACBs are tasteless to mammals. ACBs are discovered to mask the bitterness of berberine and denatonium benzoate, but not quinine hydrochloride, due to different binding modes.
- Subjects
BITTERNESS (Taste); INCLUSION compounds; BERBERINE; QUININE; ELECTROSTATIC interaction
- Publication
ChemPlusChem, 2023, Vol 88, Issue 11, p1
- ISSN
2192-6506
- Publication type
Article
- DOI
10.1002/cplu.202300465