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- Title
Rapamycin protects against early brain injury independent of cerebral blood flow changes in a mouse model of subarachnoid haemorrhage.
- Authors
Sasaki, Kazumasu; Yamamoto, Shuzo; Mutoh, Tatsushi; Tsuru, Yoshiharu; Taki, Yasuyuki; Kawashima, Ryuta
- Abstract
Summary: We evaluated the neuroprotective role of rapamycin, a mammalian target of rapamycin (mTOR) kinase inhibitor, in cerebral ischaemia and locomotor function in a mouse model of subarachnoid haemorrhage (SAH). Pretreatment with rapamycin, an mTOR kinase inhibitor, resulted in better recovery from cerebral hypoxia early after SAH than control (P < .05), while the values of peak flow velocity in the middle cerebral artery did not change significantly (P > .05). Average distance travelled and the ratio of central‐area distance/total travelled distance determined by open‐field test after day 14 was significantly higher in mice pretreated with rapamycin than in control mice (P < .05). Inhibition of the mTOR pathway could be protective against post‐SAH early brain injury, ameliorating brain tissue hypoxia and locomotor hypoactivity.
- Subjects
RAPAMYCIN; IMMUNOSUPPRESSIVE agents; CEREBRAL circulation; HYPOXEMIA; BRAIN injuries
- Publication
Clinical & Experimental Pharmacology & Physiology, 2018, Vol 45, Issue 8, p859
- ISSN
0305-1870
- Publication type
Article
- DOI
10.1111/1440-1681.12950