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- Title
Use of Single-Injection Recombinant Vesicular Stomatitis Virus Vaccine to Protect Nonhuman Primates Against Lethal Nipah Virus Disease.
- Authors
Mire, Chad E.; Geisbert, Joan B.; Agans, Krystle N.; Versteeg, Krista M.; Deer, Daniel J.; Satterfield, Benjamin A.; Fenton, Karla A.; Geisbert, Thomas W.
- Abstract
Nipah virus (NiV) is a zoonotic pathogen that causes high case-fatality rates (CFRs) in humans. Two NiV strains have caused outbreaks: the Malaysia strain (NiVM), discovered in 1998-1999 in Malaysia and Singapore (≈40% CFR); and the Bangladesh strain (NiVB), discovered in Bangladesh and India in 2001 (≈80% CFR). Recently, NiVB in African green monkeys resulted in a more severe and lethal disease than NiVM. No NiV vaccines or treatments are licensed for human use. We assessed replication-restricted single-injection recombinant vesicular stomatitis vaccine NiV vaccine vectors expressing the NiV glycoproteins against NiVB challenge in African green monkeys. All vaccinated animals survived to the study endpoint without signs of NiV disease; all showed development of NiV F Ig, NiV G IgG, or both, as well as neutralizing antibody titers. These data show protective efficacy against a stringent and relevant NiVB model of human infection.
- Subjects
BANGLADESH; MALAYSIA; INDIA; VIRAL vaccines; VESICULAR stomatitis; VIRUS diseases; NIPAH virus; CERCOPITHECUS aethiops; RESEARCH funding
- Publication
Emerging Infectious Diseases, 2019, Vol 25, Issue 6, p1144
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2506.181620