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- Title
Efficacy of phototherapy devices and outcomes among extremely low birth weight infants: multi-center observational study.
- Authors
Morris, B H; Tyson, J E; Stevenson, D K; Oh, W; Phelps, D L; O'shea, T M; Mcdavid, G E; Van Meurs, K P; Vohr, B R; Grisby, C; Yao, Q; Kandefer, S; Wallace, D; Higgins, R D
- Abstract
Objective:Evaluate the efficacy of phototherapy (PT) devices and the outcomes of extremely premature infants treated with those devices.Study Design:This substudy of the National Institute of Child Health and Human Development Neonatal Research Network PT trial included 1404 infants treated with a single type of PT device during the first 24±12 h of treatment. The absolute (primary outcome) and relative decrease in total serum bilirubin (TSB) and other measures were evaluated. For infants treated with one PT type during the 2-week intervention period (n=1223), adjusted outcomes at discharge and 18 to 22 months corrected age were determined.Result:In the first 24 h, the adjusted absolute (mean (±s.d.)) and relative (%) decrease in TSB (mg dl−1) were: light-emitting diodes (LEDs) −2.2 (±3), −22%; Spotlights −1.7 (±2), −19%; Banks −1.3 (±3), −8%; Blankets −0.8 (±3), −1%; (P<0.0002). Some findings at 18 to 22 months differed between groups.Conclusion:LEDs achieved the greatest initial absolute reduction in TSB but were similar to Spots in the other performance measures. Long-term effects of PT devices in extremely premature infants deserve rigorous evaluation.
- Subjects
PHOTOTHERAPY; BIRTH size; CHI-squared test; MEDICAL cooperation; NEONATAL intensive care; SCIENTIFIC observation; HEALTH outcome assessment; POISSON distribution; RESEARCH; RESEARCH funding; NEONATAL intensive care units; RELATIVE medical risk; TREATMENT effectiveness; DATA analysis software; DESCRIPTIVE statistics; EQUIPMENT &; supplies
- Publication
Journal of Perinatology, 2013, Vol 33, Issue 2, p126
- ISSN
0743-8346
- Publication type
Article
- DOI
10.1038/jp.2012.39