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- Title
Effects of the Inhaled Treatment of Liriope Radix on an Asthmatic Mouse Model.
- Authors
Kim, Ki-Suk; Cho, Dong-Hyuk; Yang, Hea Jung; Choi, Eun-Kyeong; Shin, Min Hee; Kim, Kang-Hoon; Ahn, Kwang Seok; Ha, In Jin; Na, Yun-Cheol; Um, Jae Young; Chung, Won Seok; Jung, Hee-Jae; Jung, Sung-Ki; Jang, Hyeung-Jin
- Abstract
As a treatment for allergic asthma, inhaled treatments such as bronchodilators that contain β2-agonists have an immediate effect, which attenuates airway obstructions and decreases airway hypersensitivity. However, bronchodilators only perform on a one off basis, but not consistently. Asthma is defined as a chronic inflammatory disease of the airways accompanying the overproduction of mucus, airway wall remodeling, bronchial hyperreactivity and airway obstruction. Liriope platyphylla radix extract (LPP), a traditional Korean medicine, has been thoroughly studied and found to be an effective anti-inflammatory medicine. Here, we demonstrate that an inhaled treatment of LPP can attenuate airway hyperresponsiveness (AHR) in an ovalbumin-induced asthmatic mouse model, compared to the saline-treated group (p < 0.01). Moreover, LPP decreases inflammatory cytokine levels, such as eotaxin (p < 0.05), IL-5 (p < 0.05), IL-13 (p < 0.001), RANTES (p < 0.01), and TNF-α (p < 0.05) in the bronchoalveolar lavage (BAL) fluid of asthmatic mice. A histopathological study was carried out to determine the effects of LPP inhalation on mice lung tissue. We performed UPLC/ESI-QTOF-MS, LC/MS, and GC/MS analyses to analyze the chemical constituents of LPP, finding that these are ophiopogonin D, spicatoside A, spicatoside B, benzyl alcohol, and 5-hydroxymethylfurfural. This study demonstrates the effect of an inhaled LPP treatment both on airway AHR and on the inflammatory response in an asthmatic mouse model. Hence, LPP holds significant promise as a nasal inhalant for the treatment of asthmatic airway disease.
- Subjects
DRUG therapy for asthma; ANALYSIS of variance; ANIMAL experimentation; ASTHMA; BIOLOGICAL assay; BIOLOGICAL models; CHROMATOGRAPHIC analysis; CYTOKINES; ENZYME-linked immunosorbent assay; LUNGS; MASS spectrometry; BOTANIC medicine; MICE; MOLECULAR structure; RESEARCH funding; RESPIRATORY organs; STATISTICS; T-test (Statistics); PLANT extracts; DATA analysis; ALBUMINS; DATA analysis software; DESCRIPTIVE statistics
- Publication
American Journal of Chinese Medicine, 2015, Vol 43, Issue 3, p425
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X15500275