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- Title
Chemical Composition Analysis, Antioxidant, Antiglycating Activities and Neuroprotective Effects of S. choloroleuca, S. mirzayanii and S. santolinifolia from Iran.
- Authors
Asadi, Sareh; Khodagholi, Fariba; Esmaeili, Mohammad Ali; Tusi, Solaleh Khoramian; Ansari, Niloufar; Shaerzadeh, Fatemeh; Sonboli, Ali; Ghahremanzamaneh, Mina
- Abstract
This study was designed to examine antioxidant activities, antiglycating abilities and neuroprotective effects of methanolic extracts of Salvia choloroleuca, Salvia santolinifolia and Salvia mirzayanii from Iran. The extracts were screened for their possible antioxidant activities by several biochemical assays such as DPPH, FRAP, β-carotene bleaching and TEAC assays. HPLC analysis of these extracts led to the separation of a number of components such as catechine and rosmarinic acid. Based on our results, all these plants had antioxidant and antiglycating activities, among them S. choloroleuca seems to be the most effective one. Furthermore, these species not only showed no cytotoxic effects in neuron-like PC12 cells, but also protected them against oxidative stress-induced cell death, exerted by H2O2. We further showed that these plants increase superoxide dismutase and catalase levels, reduce lipid peroxidation and up regulate hemeoxygenase-1 and glutamylcysteine synthetase proteins. This study raised the possibility of developing these plants as potential neuroprotective agents.
- Subjects
IRAN; ANALYSIS of variance; ANIMAL experimentation; ANTIOXIDANTS; BIOLOGICAL assay; CATTLE; CHEMICAL reagents; FREE radicals; HIGH performance liquid chromatography; HORSES; MEDICINAL plants; LIPID peroxidation (Biology); METHANOL; OXIDOREDUCTASES; RATS; RESEARCH funding; SUPEROXIDE dismutase; WESTERN immunoblotting; OXIDATIVE stress; NEUROPROTECTIVE agents; PHARMACODYNAMICS
- Publication
American Journal of Chinese Medicine, 2011, Vol 39, Issue 3, p615
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X1100907X