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- Title
High-risk syndrome for neuromyelitis optica: a descriptive and comparative study.
- Authors
Collongues, N.; Marignier, R.; Zéphir, H.; Blanc, F.; Vukusic, S.; Outteryck, O.; Fleury, M.; Ruet, A.; Borgel, F.; Thouvenot, E.; Moreau, T.; Defer, G.; Derache, N.; Pelletier, J.; Audoin, B.; Debouverie, M.; Labauge, P.; Gout, O.; Camu, W.; Brassat, D.
- Abstract
Background: Neuromyelitis optica (NMO) frequently begins with a monofocal episode of optic neuritis or myelitis. A concept named high-risk syndrome (HRS) for NMO has been proposed for patients with monofocal episodes and NMO-IgG antibodies.Objective: To describe HRS patients and compare them with NMO patients.Methods: We identified 30 patients with HRS: 18 with extensive myelitis (HRM) and 12 with optic neuritis (HRON), in a database pooling patients from 25 centres in France. Clinical, laboratory/magnetic resonance imaging (MRI) data and outcome were analysed and compared with a national cohort of 125 NMO patients extracted from the same database.Results: Mean follow-up was 4.8 years. Mean age at onset was 42.8 years (range: 12.4–70) with a female:male ratio of 0.9. Asymptomatic lesions were report on visual evoked potentials in 4/8 tested HRM patients and on spinal cord MRI in 2/7 HRON patients. Three patients died, two owing to a cervical lesion. HRS and NMO patients had similar clinical/paraclinical data, except for a predominance of men in the HRS group and a later mean age at onset in the HRM subgroup.Conclusion: The description of HRS patients is compatible with a monofocal form of NMO. Asymptomatic lesions could be included in a new set of NMO diagnostic criteria.
- Subjects
FRANCE; OPTIC neuritis; MYELITIS; IMMUNOGLOBULIN G; COHORT analysis; MAGNETIC resonance imaging; THERAPEUTICS
- Publication
Multiple Sclerosis Journal, 2011, Vol 17, Issue 6, p720
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458510396923