We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Optimal Management of Patients With Non-Ulcer Dyspepsia: Considerations for the Treatment of the Elderly.
- Authors
Asante, M.A.
- Abstract
Optimal therapy for patients with non-ulcer dyspepsia still remains elusive. Increasing consensus on the definition of non-ulcer dyspepsia may improve the design of clinical trials and result in more effective therapies for this common condition. This paper reviews the investigation, pathophysiology and therapy of non-ulcer dyspepsia in order to formulate management strategies in the elderly. The best outcome for the patient can be achieved by detailed evaluation, leading to therapy targeted to obvious precipitating factors such as dyspepsia-inducing medications and other aggravating factors such as slow-transit constipation. Prokinetics and, to a lesser extent, H receptor antagonists are the main medications of choice. Cisapride, the best studied prokinetic, has been withdrawn from the market in certain countries because some patients experienced dangerous cardiac arrhythmias, especially when cisapride was given with potent inhibitors of cytochrome P450 3A4. Time spent on reassurance and judicious use of antidepressants for the right patient can help improve symptoms. In the elderly, however, persistent symptoms should be re-evaluated because of the increased incidence of malignancy.
- Subjects
INDIGESTION treatment; TREATMENT of diseases in older people; ANTIDEPRESSANTS
- Publication
Drugs & Aging, 2001, Vol 18, Issue 11, p819
- ISSN
1170-229X
- Publication type
Article
- DOI
10.2165/00002512-200118110-00003