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- Title
Preservative-Free Prostaglandin Analogs and Prostaglandin/Timolol Fixed Combinations in the Treatment of Glaucoma: Efficacy, Safety and Potential Advantages.
- Authors
Holló, Gábor; Katsanos, Andreas; Boboridis, Kostas; Irkec, Murat; Konstas, Anastasios
- Abstract
Glaucoma therapy-related ocular surface disease (OSD) is a serious pathology with a broad spectrum of insidious clinical presentations and complex pathogenesis that undermines long-term glaucoma care. Preservatives, especially benzalkonium chloride (BAK), contained in topical intraocular pressure-lowering medications frequently cause or aggravate OSD in glaucoma. Management of these patients is challenging, and to date often empirical due to the scarcity of controlled long-term clinical trials. Most of the available data are extracted from case series and retrospective analysis. Preservative-free prostaglandins and prostaglandin/timolol fixed combinations are novel options developed to remove the harmful impact of preservatives, especially BAK, upon ocular tissues. Based on what is currently known on the value of preservative-free antiglaucoma therapies it is tempting to speculate how these new therapies may affect the future medical management of all glaucoma patients. This article provides a comprehensive and critical review of the current literature on preservative-free prostaglandins and preservative-free prostaglandin/timolol fixed combinations.
- Subjects
PROSTAGLANDINS; TIMOLOL maleate; ANTI-infective agents; COMBINATION drug therapy; EYE diseases; GLAUCOMA; SYSTEMATIC reviews; TREATMENT effectiveness; DRUG additives; THERAPEUTICS
- Publication
Drugs, 2018, Vol 78, Issue 1, p39
- ISSN
0012-6667
- Publication type
Article
- DOI
10.1007/s40265-017-0843-9