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- Title
Pilot study on gut microbiota profile in Indian children with type 1 diabetes.
- Authors
Shah, Nikhil; Kulkarni, Abhijit; Mongad, Dattatray; Jaani, Kunal; Kajale, Neha; Tamahane, Vaishali; Bhor, Shital; Ladkat, Dipali; Khadilkar, Vaman; Gondhalekar, Ketan; Shouche, Yogesh; Khadilkar, Anuradha
- Abstract
Background: Non-genetic factors like microbial dysbiosis may be contributing to the increasing incidence/progression of type 1 diabetes mellitus (T1DM). Objectives: To analyse the gut microbiota profile in Indian children with T1DM and its effect on glycaemic control. Methodology: Faecal samples of 29 children with T1DM were collected and faecal microbial DNA was extracted and subjected to 16S rRNA (ribosomal RNA) sequencing and further analysis. Results: The dominant phyla in children with T1DM were Firmicutes and Bacteroidetes. Butyrate-producing bacteria Blautia and Ruminococcus showed a significant negative correlation with the glycosylated haemoglobin (HbA1C) levels (p < 0.05). Coprococcus and Propionibacterium were important negative predictors of glycaemic control (p < 0.05). Conclusion: Our study suggests that Indian children with T1DM have a distinct gut microbiome taxonomic composition and that short-chain fatty acid-producing bacteria like Ruminococcus and Blautia (butyrate-producing) may play an important role in the glycaemic control of subjects with T1DM.
- Subjects
INDIA; TYPE 1 diabetes; RIBOSOMAL DNA; BUTYRATES; GUT microbiome; GLYCEMIC control; RIBOSOMAL RNA; PILOT projects
- Publication
Indian Journal of Endocrinology & Metabolism, 2023, Vol 27, Issue 5, p404
- ISSN
2230-8210
- Publication type
Article
- DOI
10.4103/ijem.ijem_22_22