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- Title
Profile of paediatric hypothyroidism in a Tertiary Care Centre.
- Authors
Rajitha, D.; Sunil, E.; Suresh, V.; Rajagopal, G.; Kumar, P. Satish; Sachan, Alok
- Abstract
Introduction: There is a paucity of Indian observational data on growth in hypothyroid children. Objectives: To study the therapeutic benefit of thyroxin (T4) on growth of children in the initial 2 years of treatment in newly diagnosed primary hypothyroidism. Materials and Methods: Paediatric patients with a diagnosis of primary hypothyroidism (i.e. Thyrotropin (TSH) >15 mIU/ml and T4 < 55 ng/ml) were included. Treatment was started with thyroxin. Dose was adjusted to maintain TSH between 0.5-5 mIU/ml. Height, height standard deviation scores (HSDS) and TSH were measured at baseline and at every follow-up visit. Height velocity in the initial couple of years was measured in cm/person year of use of thyroxin. Results: Forty-four children (female:male ratio of 2.67:1) with newly diagnosed primary hypothyroidism were included in this study. The mean duration of follow-up was 13.9 months. Mean dose of thyroxin per kg body weight required to restore euthyroidism was 4.14 ± 2.45 µg. The dose per kg fell from 4.76 ± 2 µg in preschool children to 3.04 ± 1.5 µg in adolescence (P < 0.05).The initial height SDS was -2.42 ± 2.58 and this improved by 0.45 ± 1.06 to final value of -1.86 ± 2.14 (P value < 0.05). The post-treatment catch up growth was 7.8 cm/person year of use. Conclusion: The height SDS deficit because of hypothyroidism is only partially regained in the first couple of years after treatment. However, follow-up until the attainment of final height is needed.
- Subjects
HYPOTHYROIDISM in children; THYROXINE; STATURE; PRESCHOOL children; ADOLESCENCE; THERAPEUTICS
- Publication
Indian Journal of Endocrinology & Metabolism, 2012, Vol 16, pS516
- ISSN
2230-8210
- Publication type
Article