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- Title
Synthesis of 1,4,7,10-Tetra-azacyclododecan-1,4,7,10-tetra-azidoethylacetic Acid (DOTAZA) and Related 'Clickable' DOTA Derivatives.
- Authors
Kriemen, Ella; Ruf, Erik; Behrens, Ulrich; Maison, Wolfgang
- Abstract
Herein, we report the synthesis of two enantiomeric DOTAZA esters and a related DOT3AZA ester. These compounds are tunable analogues of the well-known chelator DOTA and can be easily functionalized through click chemistry of the side-chain azide groups. Like DOTA, DOTAZA forms complexes with various di- and trivalent metals, as demonstrated in the synthesis and structural analysis of CuDOTAZA and the preparation of GdDOTAZA.
- Subjects
CHEMICAL synthesis; ESTERS; AZIDES; NITROGEN compound synthesis; IRON chelates
- Publication
Chemistry - An Asian Journal, 2014, Vol 9, Issue 8, p2197
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.201402250