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- Title
Long Survival of a Small-Cell Lung Cancer Patient Who Received Maintenance Chemotherapy with Irinotecan.
- Authors
Yagi, Yoshitaka; Kim, Young Hak; Tajima, Noriyuki; Baba, Kiichiro; Aihara, Kensaku; Soo, Hong Hyun; Yamaoka, Shinpachi; Mishima, Michiaki
- Abstract
Lung cancer is the leading cause of cancer-related death worldwide. Small-cell lung cancer (SCLC) accounts for approximately 15% of all lung cancers. It is characterized by rapid tumor growth and early metastasis to multiple organs. Response to initial chemotherapy is generally good; however, the majority of patients develop recurrence and the prognosis of such patients is reportedly 2-4 months. Evolution of the treatment for SCLC has stagnated, and cisplatin + etoposide has been the standard chemotherapy for decades. Meanwhile, the combination of cisplatin + irinotecan has demonstrated equivalent efficacy to cisplatin + etoposide. Recently, maintenance chemotherapy has been extensively investigated in non-small-cell lung cancer (NSCLC), and is currently recommended as a standard treatment in clinical guidelines. On the contrary, a maintenance strategy has not been established for SCLC. Here, we describe an SCLC patient who received maintenance chemotherapy with irinotecan for more than 2 years after induction chemotherapy with cisplatin + irinotecan, and survived long term with no recurrence. © 2013 S. Karger AG, Basel
- Publication
Case Reports in Oncology, 2013, Vol 6, Issue 3, p569
- ISSN
1662-6575
- Publication type
Article
- DOI
10.1159/000356826