We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
CRYSTALLINE FORMS OF BETULIN: POLYMORPHISM OR PSEUDOPOLYMORPHISM?
- Authors
Drebushchak, T. N.; Mikhailovskaya, A. V.; Drebushchak, V. A.; Mikhailenko, M. A.; Myz', S. A.; Shakhtshneider, T. P.; Kuznetsova, S. A.
- Abstract
By recrystallization with different solvents as well as decomposition of betulin ethanol solvate at room temperature a new crystalline form of the biologically active compound betulin, namely hemihydrate of betulin, is obtained. By single crystal X-ray diffraction data the crystal structure of hemihydrate of betulin is determined. By powder X-ray thermodiffraction and differential scanning calorimetry it is found that when hemihydrate of betulin is heated to melting, Н2О molecules are removed and solid-phase transformations occur, which are related to the formation of an intermediate crystalline form and an orthorhombic modification of betulin.
- Subjects
BETULIN; BIOACTIVE compounds; DIFFERENTIAL scanning calorimetry; SINGLE crystals
- Publication
Journal of Structural Chemistry, 2020, Vol 61, Issue 8, p1260
- ISSN
0022-4766
- Publication type
Article
- DOI
10.1134/S0022476620080119