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- Title
Association Between a Chloride-Liberal vs Chloride-Restrictive Intravenous Fluid Administration Strategy and Kidney Injury in Critically Ill Adults.
- Authors
Mohd Yunos, Nor'azim; Bellomo, Rinaldo; Hegarty, Colin; Story, David; Ho, Lisa; Bailey, Michael
- Abstract
The article discusses the effect of chloride-restrictive and chloride-liberal intravenous fluid strategy in acute kidney injury (AKI). The study reveals that risk of AKI in critically ill patients, a chloride-restrictive intravenous fluids strategy cause decrease incidence of AKI as compared to chloride-liberal intravenous strategy. It states that in Chloride-liberal strategy the fluids used for hydration induces hyperchloremia and metabolic acidosis which may cause renal vasoconstriction and decreased glomerular filtration rate (GFR). It further informs that the implementation of a chloride-restrictive strategy decreases the incidence of AKI and the use of renal replacement therapy.
- Subjects
KIDNEY disease treatments; RENAL pharmacology; PHYSIOLOGICAL effects of chlorides; CHLOROSIS; ACIDOSIS; KIDNEY glomerulus; RENAL circulation; KIDNEY transplantation
- Publication
JAMA: Journal of the American Medical Association, 2012, Vol 308, Issue 15, p1566
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2012.13356