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- Title
Association of Occult Metastases in Sentinel Lymph Nodes and Bone Marrow With Survival Among Women With Early-Stage Invasive Breast Cancer.
- Authors
Giuliano, Armando E.; Hawes, Debra; Ballman, Karla V.; Whitworth, Pat W.; Blumencranz, Peter W.; Reintgen, Douglas S.; Morrow, Monica; Leitch, A. Marilyn; Hunt, Kelly K.; McCall, Linda M.; Abati, Andrea; Cote, Richard
- Abstract
The article discusses a research study which examined the association between survival and occult metastases detected by immunochemical staining of sentinel lymph nodes and bone marrow specimens from female patients with early-stage invasive breast cancer. Results of immunochemical staining showed that 76.3 percent of the SLN specimens were tumor-negative and 10.5 percent were tumor-positive, while 3.0 percent of bone marrow specimens were positive for tumors. Data reveals that 435 patients had died and 376 had disease recurrence. Evidence showed the insignificant association of SLN metastases with overall survival, while bone marrow metastases were found to be associated with decreased overall survival.
- Subjects
METASTASIS; LYMPH nodes; BONE marrow; TUMORS; BREAST cancer; CANCER patients
- Publication
JAMA: Journal of the American Medical Association, 2011, Vol 306, Issue 4, p385
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2011.1034