We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Clinico-haematological studies on experimental Cryptosporidium parvum Jammu isolate infection in Swiss albino mice.
- Authors
Bhagat, Meenakshi; Sood, Shilpa; Yadav, Anish; Katoch, Rajesh; Chakraborty, Dibyendu; Godara, Rajesh; Sultana, Mudasir; Sangha, Navrose
- Abstract
The present study was conducted to determine the clinco-haematological effects of a well characterized Cryptosporidium parvum isolate in Swiss albino mice. Sixty female mice were divided into four groups. Group I mice served as healthy control. In group II, C. parvum oocysts were administered orally, mice of group III were given dexamethasone in drinking water whereas group IV mice were given dexamethasone along with C. parvum oocysts. Clinical signs were more severe in immunosuppressed infected mice and observed dullness, depression, inappetance, poor fur condition, progressive weakness, and decrease in body weight. In addition, mice in group IV showed profuse diarrhoea. An overall mortality rate of 7% and 20% was seen in group III and IV animals, respectively. Animals of group IV had significantly lower average body weight as compared to other groups around the time of peak infection with C. parvum which was recorded to be around 10th DPI. Based on severity of clinical disease and oocyst shedding intensity significant leukocytosis along with neutrophilia and lymphocytopenia was observed in group IV mice at 10th DPI as compared to mice in other groups. It was concluded that experimental infection with C. parvum in mice caused a severe clinical disease which peaked around 10th day and was seen to subsequently resolve around 15 DPI.
- Subjects
CRYPTOSPORIDIUM parvum; MOUSE diseases; HEMATOLOGY; DEXAMETHASONE; ANIMAL mortality; IMMUNOSUPPRESSION
- Publication
Indian Journal of Animal Research, 2018, Vol 52, Issue 7, p1025
- ISSN
0367-6722
- Publication type
Article
- DOI
10.18805/ijar.B-3318