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- Title
HCV Infection and B-Cell Lymphomagenesis.
- Authors
Ito, Masahiko; Kusunok, Hideki; Mochida, Keiko; Yamaguchi, Kazunari; Mizuochi, Toshiaki
- Abstract
Hepatitis C virus (HCV) has been recognized as a major cause of chronic liver diseases worldwide. It has been suggested that HCV infects not only hepatocytes but also mononuclear lymphocytes including B cells that express the CD81 molecule, a putative HCV receptor. HCV infection of B cells is the likely cause of B-cell dysregulation disorders such as mixed cryoglobulinemia, rheumatoid factor production, and B-cell lymphoproliferative disorders that may evolve into non-Hodgkin's lymphoma (NHL). Epidemiological data indicate an association between HCV chronic infection and the occurrence of B-cell NHL, suggesting that chronic HCV infection is associated at least in part with B-cell lymphomagenesis. In this paper, we aim to provide an overview of recent literature, including our own, to elucidate a possible role of HCV chronic infection in B-cell lymphomagenesis.
- Subjects
HEPATITIS C virus; LYMPHOCYTES; B cells; CD8 antigen; CRYOGLOBULINEMIA; PARAPROTEINEMIA; HEMATOLOGY
- Publication
Advances in Hematology, 2011, Vol 2011, p1
- ISSN
1687-9104
- Publication type
Article
- DOI
10.1155/2011/835314