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- Title
Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant.
- Authors
Tian, Miao; Mochizuki, Kazufumi; Loidl, Josef
- Abstract
Meiotic DNA double-strand breaks produce reciprocally exchanged DNA strands, which mature into chiasmata that hold homologous chromosomes together as bivalents. These bivalents are subsequently separated in the first meiotic division. In a mutant lacking the newly identified Tetrahymena gene APRO1 (Anaphase promoting 1), meiosis is arrested by the end of prophase. Mature chiasmata are not formed but bivalents are connected via a molecular precursor structure. In-depth analysis of this arrested intermediate structure may help to elucidate the noncanonical molecular recombination pathway in Tetrahymena.
- Subjects
TETRAHYMENA; DOUBLE-strand DNA breaks; HOMOLOGOUS chromosomes; MOLECULAR structure; HOLLIDAY junctions; CROSSING over (Genetics); MEIOSIS
- Publication
PLoS ONE, 2022, Vol 17, Issue 2, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0263691