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- Title
Opioids and opioid receptors in multiple sclerosis.
- Authors
Mirshafiey, Abbas; Mohsenzadegan, Monireh
- Abstract
Central neuropathic pain is common in multiple sclerosis (MS) initiated or caused by a primary lesion or dysfunction of the central nervous system, occurs in about 28% of patients with multiple sclerosis. The mechanistic basis for this increased nociception is currently poorly understood. The opioids provide excellent pain relief in most patients. While neuropathic pain in MS is poorly responsive but not totally unresponsive to opioids. The results do not support the routine use of strong opioids in MS patients with central pain. The possible link between the opioid peptides and the heterogeneity of the clinical course of multiple sclerosis was investigated. Based on the researches that have been carried out, they become apparent that ongoing learning about receptor subtypes and related opioid analgesics must take place to understand the complexity of pain management. In this article, our aim is to investigate the mechanism of effect opioid and opioid receptor and describe previous experiments as application cases of opioids and opiates for pain relief in MS patients.
- Subjects
OPIOID receptors; MULTIPLE sclerosis research; NEUROPATHY; PAIN management; NOCICEPTORS; DRUG efficacy; CENTRAL pain; PSYCHIATRIC drugs; PHYSIOLOGICAL effects of narcotics
- Publication
Journal of Chinese Clinical Medicine, 2010, Vol 5, Issue 3, p171
- ISSN
1562-9023
- Publication type
Article