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- Title
Endoglin: a critical mediator of cardiovascular health.
- Authors
Kapur, Navin K.; Morine, Kevin J.; Letarte, Michelle
- Abstract
Endoglin (CD105) is a type III auxiliary receptor for the transforming growth factor beta (TGFβ) superfamily. Several lines of evidence suggest that endoglin plays a critical role in maintaining cardiovascular homeostasis. Seemingly disparate disease conditions, including hereditary hemorrhagic telangiectasia, pre-eclampsia, and cardiac fibrosis, have now been associated with endoglin. Given the central role of the TGFβ superfamily in multiple disease conditions, this review provides a detailed update on endoglin as an evolving therapeutic target in the management of cardiovascular disease.
- Subjects
ENDOGLIN; CARDIOVASCULAR agents; TRANSFORMING growth factors-beta; VENTRICULAR remodeling; HOMEOSTASIS; HEMORRHAGIC diseases; CARDIOVASCULAR diseases
- Publication
Vascular Health & Risk Management, 2013, Vol 9, p195
- ISSN
1176-6344
- Publication type
Article
- DOI
10.2147/VHRM.S29144