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- Title
Astragalin Attenuates Allergic Inflammation in a Murine Asthma Model.
- Authors
Liu, Jiping; Cheng, Yue; Zhang, Xiaoshuang; Zhang, Xue; Chen, Shuxian; Hu, Zongmiao; Zhou, Chunmei; Zhang, Enhu; Ma, Shiping
- Abstract
The present study aimed to determine the protective effects and the underlying mechanisms of astragalin (AG) on ovalbumin (OVA)-induced allergic inflammation in a mouse model of allergic asthma. Our study demonstrated that AG inhibited OVA-induced increases in eosinophil count; IL-4, IL-5, IL-13, and IgE were recovered in bronchoalveolar lavage fluid, and increased IFN-γ level in bronchoalveolar lavage fluid. Histological studies demonstrated that AG substantially inhibited OVA-induced eosinophilia in lung tissue. Western blot analysis demonstrated that AG treatments markedly inhibited OVA-induced SOCS-3 expression and enhancement of SOCS-5 expression in an asthma model. Our findings support the possible use of AG as a therapeutic drug for patients with allergic asthma.
- Subjects
INFLAMMATION; OVALBUMINS; ASTHMA risk factors; BRONCHOALVEOLAR lavage; ALLERGIES; EOSINOPHILIA
- Publication
Inflammation, 2015, Vol 38, Issue 5, p2007
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-015-0181-6