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- Title
Convergent Domino Cyclization: Oxidative [3+1+1] Annulation for One‐Pot Synthesis of 2‐Quinoline‐4,5‐diaryl‐oxazoles from Methyl Azaarenes, Benzoins and NH<sub>4</sub>OAc.
- Authors
Liang, Fei‐Fei; Liu, Kai‐Xuan; Zhao, Cong; Shang, Zhi‐Hao; Kong, Hong‐Mei; Yin, Ya‐Qing; Zhu, Yan‐Ping; Sun, Yuan‐Yuan; Yao, Jian‐Wen
- Abstract
An oxidative [3+1+1] convergent domino cyclization is disclosed. This protocol enables to get quinoline, quinoxaline, quinazolin‐4(3H)‐one and benzo[d]thiazole attached 2,4,5‐trisubstituted oxazoles from methyl azaarenes, benzoins, and NH4OAc in the presence of iodine and molecular sieves without any metal catalyst. The reaction features wide substrate scope, good functional group tolerance, mild reaction conditions, and easily available substrates.
- Subjects
BENZOIN; AZAARENES; ANNULATION; RING formation (Chemistry); MOLECULAR sieves
- Publication
European Journal of Organic Chemistry, 2021, Vol 2021, Issue 6, p998
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202001561