We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Comparative Effectiveness of Varenicline and Nicotine Patches for Smoking Abstinence During Pregnancy: Evidence From a Population-based Cohort Study.
- Authors
Choi, Stephanie K Y; Tran, Duong T; Kemp-Casey, Anna; Preen, David B; Randall, Deborah; Einarsdottir, Kristjana; Jorm, Louisa R; Havard, Alys
- Abstract
<bold>Introduction: </bold>In the general population, varenicline is consistently shown to be more efficacious for smoking cessation than nicotine replacement therapy (NRT). Current clinical guidelines for the management of smoking during pregnancy recommend against the use of varenicline, whilst supporting the use of NRT. However, little is known about the comparative effectiveness of these smoking cessation therapies among pregnant women.<bold>Aims and Methods: </bold>Routinely-collected records of all births in two Australian States during 2011 and 2012 were used to create a population-based cohort of women who smoked during the first half of pregnancy. Pharmaceutical dispensing data were used to identify varenicline and nicotine patch dispensings in the first half of pregnancy. Propensity score matching was used to account for the potentially different distribution of confounding factors between the treatment groups. The outcome was defined as smoking abstinence during the second half of pregnancy.<bold>Results: </bold>After propensity score-matching, our cohort comprised 60 women who used varenicline and 60 who used nicotine patches during the first half of pregnancy. More varenicline users (33.3%, 95% CI: 21.7%-46.7%) quit smoking than nicotine patch users (13.3%, 95% CI: 5.9%-24.6%). The adjusted rate difference was 24.2% (95% CI: 10.2%-38.2%) and the adjusted relative risk was 2.8 (95% CI: 1.4-5.7).<bold>Conclusions: </bold>Varenicline was almost three times more effective than nicotine patches in assisting pregnant women to quit smoking. Further studies are needed to corroborate our results. Together with data on the safety of varenicline during pregnancy, evidence regarding the relative benefit of varenicline and NRT during pregnancy important for informing clinical decisions for pregnant smokers.<bold>Implications: </bold>This study is the first to measure the comparative effectiveness of varenicline and nicotine patches during pregnancy - women using varenicline were almost three times as likely to quit smoking than those using nicotine patches. This study addressed a clinically important question using an observational study, noting that there is an absence of evidence from randomized controlled trials because of the ethical issues associated with including pregnant women in clinical trials of medicines of unknown safety.
- Subjects
AUSTRALIA; NICOTINE replacement therapy; VARENICLINE; TEMPERANCE; SMOKING cessation; PROPENSITY score matching; RESEARCH; RESEARCH methodology; NICOTINE; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; SMOKING; LONGITUDINAL method
- Publication
Nicotine & Tobacco Research, 2021, Vol 23, Issue 10, p1664
- ISSN
1462-2203
- Publication type
journal article
- DOI
10.1093/ntr/ntab063