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- Title
Allo-non-specific elevation of maternal killer cell activity in intrauterine growth restriction.
- Authors
Fujii, T.; Tsushima, R.; Okai, T.; Shibata, Y.; Taketani, Y.
- Abstract
<bold>Objective: </bold>In order to gain insight into the pathogenesis of intrauterine growth restriction (IUGR) of the fetus, we evaluated the cytotoxic activity of lymphocytes towards fetal cells in pregnancies complicated by IUGR.<bold>Methods: </bold>We performed a cytotoxic assay using the maternal lymphocyte-derived lymphokine activated killer (LAK) cells as the effector cells. Cord vessel endothelial cells were used as the target cells.<bold>Results: </bold>LAK cells in pregnancies complicated by IUGR demonstrated higher killer cell activities against IUGR fetus-derived endothelial cells compared with LAK cells from uncomplicated pregnancies against the same endothelial cells. However, when non-IUGR fetus-derived endothelial cells were used as the target cells, LAK cells of pregnant women with IUGR exhibited essentially the same activities as those of normal pregnant women.<bold>Conclusion: </bold>The results suggest that lymphocytes in pregnancies complicated by IUGR may have enhanced killer cell activities towards the IUGR fetus in an allo-non-specific way.
- Publication
International Journal of Gynecology & Obstetrics, 1996, Vol 52, Issue 3, p237
- ISSN
0020-7292
- Publication type
journal article
- DOI
10.1016/0020-7292(95)02609-6