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- Title
Infliximab and Plant-Based Diet as First-Line Therapy Followed by Corticosteroid Therapy for Severe Ulcerative Colitis: A Case Report.
- Authors
Chiba, Mitsuro; Tsuji, Tsuyotoshi; Masai, Rie; Odashima, Masaru; Sageshima, Masato
- Abstract
We developed infliximab and a plant-based diet as first-line (IPF) therapies for severe ulcerative colitis (UC). It increased the remission rate and decreased the colectomy rate compared to those of current standards. We encountered a case with severe UC in which the consecutive use of IPF therapy and corticosteroid therapy was required to induce remission. A 21-year-old male worker developed diarrhea, abdominal pain, marked weight loss from 70 to 55 kg, and anorexia. He was diagnosed with severe ulcerative colitis. IPF therapy was initiated. Improvement in symptoms and biomarkers was seen soon after the first infusion of infliximab (300 mg). Further improvement in symptoms was observed after both the second and third infliximab infusions. Loose stool and abdominal pain on defecation were still present, however, and biomarkers were above the reference range. Therefore, oral prednisolone (40 mg/day) was consecutively initiated. This resulted in clinical and endoscopic remission. In conclusion, we present a severe UC case in which the response to IPF therapy was insufficient. Consecutive oral prednisolone successfully induced remission. This new stepwise modality will make IPF therapy the first-choice therapy for severe UC.
- Subjects
ULCERATIVE colitis; BIOMARKERS; ADRENOCORTICAL hormones; PREDNISOLONE; DIARRHEA; INFLIXIMAB; ANTINEUTROPHIL cytoplasmic antibodies; PLANT-based diet; SEVERITY of illness index; WEIGHT loss; ABDOMINAL pain; ANOREXIA nervosa
- Publication
Gastrointestinal Disorders, 2022, Vol 4, Issue 4, p230
- ISSN
2624-5647
- Publication type
Article
- DOI
10.3390/gidisord4040022