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- Title
Solid Phase Extraction over Liquid-Liquid Extraction of Cephalosporin and Carbapenem antibiotics in forensic samples.
- Authors
Singh, Jaskaran; Shukla, Sudhir Kumar; Sharma, Madhulika; Kataria, Suraj; Kumar, Jitendra
- Abstract
Sample preparation is an important step for analytical procedures in forensic labs which include clean-up process, isolation and extraction of desired analytes at trace levels. The present paper describes the application of simple cleanup process, isolation and miniaturized extraction procedures such as Solid Phase Extraction (S.P.E.) and Liquid-Liquid Extraction (L.L.E.) for separation of cephalosporin and carbapenem antibiotics in forensic biological specimens. The cleanup process is based on the nature of protein and fat molecules present in Biological specimens (Gastric lavage, Viscera and Blood) which creates hindrances in identification of target drug. S.P.E. has been used as an effective, environmental friendly, economical and proficient technique in separating drug from forensic biological specimens with high quality yield of recovery. A comparison is carried out between S.P.E. and conventional L.L.E. for extraction of drug from biological matrices which showed that S.P.E. is the better technique for sample extraction and preparation of various biological specimens with trace level of analytes.
- Subjects
SOLID phase extraction; LIQUID-liquid extraction; BIOLOGICAL specimens; CEPHALOSPORINS; ANTIBIOTICS; BIOMOLECULES
- Publication
Anil Aggrawal's Internet Journal of Forensic Medicine & Toxicology, 2018, Vol 19, Issue 2, p1
- ISSN
0972-8074
- Publication type
Article