We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Documenting Foci of Hepatocellular Alteration in Two-Year Carcinogenicity Studies: Current Practices of the National Toxicology Program.
- Authors
Maronpot, Robert R.; Harada, Takanori; Murthy, A. S. K.; Boorman, Gary A.
- Abstract
Altered hepatocellular foci (AHF) can be reliably identified in hematoxylin and cosin (H&E)-stained sections of liver from interim and final sacrifice intervals in 2-yr carcinogenicity studies in rats. While most AHF can be categorized on the basis of a defined set of descriptive terms, viz., basophilic, eosinophilic, clear, vacuolated, and mixed foci, exposure to hepatocarcinogenic agents may induce unique types of AHF which should be distinguished from those that occur more commonly. It is proposed that unique treatment-associated AHF be classified as atypical AHF and that they be completely described in the pathology narrative accompanying the study. Since profound changes in the number and size of AHF have been documented in Fischer 344 rats with mononuclear cell leukemia, it is recommended that liver focus data from leukemic animals be censored in assessing potential effects of treatment on AHF. At the present time, there are insufficient data to allow routine use of AHF in regulatory decision-making in the absence of a liver tumor response. However, such data may form part of weight-of-evidence considerations used by regulatory bodies when accompanied by a concomitant liver tumor response.
- Publication
Toxicologic Pathology, 1989, Vol 17_4, Issue PT1, p675
- ISSN
0192-6233
- Publication type
Article
- DOI
10.1177/019262338901700412