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- Title
Effects of phosphodieastrase type 5 inhibitions on morphine withdrawal symptoms in mice.
- Authors
Mahmoodi, Minoo; Shahidi, Siamak; Hashemi-Firouzi, Nasrin
- Abstract
Background: Chronic morphine exposure creates dependence and, upon cessation, withdrawal symptoms. Studies indicate the phosphodiesterase type 5 (PDE5) inhibitor sildenafil may provide centrally mediated benefits against withdrawal, and therefore, this study evaluated morphine withdrawal signs in dependent mice with and without sildenafil treatment. Method: Dependence was induced by repeated treatments with morphine over 5 consecutive days. The morphine-dependent mice received sildenafil (1, 5, 10, or 20 mg/kg, i.p.) 15 min prior to the precipitation of morphine withdrawal. On the last day, naloxone was injected 2 hours after the last morphine injection, and withdrawal signs were evaluated for 30 min after naloxone injection. Results: The administration of sildenafil reduced all of the morphine withdrawal symptoms. Conclusions: The administration of sildenafil diminished morphine withdrawal signs in morphine-dependent mice. We hypothesize that the mechanism involves enhanced cyclic guanosine monophosphate (cGMP) activity, but further studies are recommended for a better understanding.
- Subjects
TREATMENT of drug withdrawal symptoms; PHOSPHODIESTERASE-5 inhibitors; DETOXIFICATION (Substance abuse treatment); LABORATORY mice; MORPHINE abuse; SILDENAFIL; CYCLIC nucleotide phosphodiesterase inhibitors; THERAPEUTICS
- Publication
Psicothema, 2014, Vol 26, Issue 4, p511
- ISSN
0214-9915
- Publication type
Article
- DOI
10.7334/psicothema2014.36