We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF.
- Authors
Grell, Matthias; Zimmermann, Gudrun; Gottfried, Eva; Chun-Ming Chen; Grünwald, Uli; Huang, David C. S.; Yan-Hwa Wu Lee; Dürkop, Horst; Engelmann, Hartmut; Scheurich, Peter; Wajant, Harald; Strasser, Andreas
- Abstract
Several members of the tumour necrosis factor receptor (TNF-R) superfamily can induce cell death. For TNF-R1, Fas/APO-1, DR3, DR6, TRAIL-R1 and TRAIL-R2, a conserved ‘death domain’ in the intracellular region couples these receptors to activation of caspases. However, it is not yet known how TNF receptor family members lacking a death domain, such as TNF-R2, CD40, LT-βR, CD27 or CD30, execute their death-inducing capability. Here we demonstrate in different cellular systems that cytotoxic effects induced by TNF-R2, CD40 and CD30 are mediated by endogenous production of TNF and autotropic or paratropic activation of TNF-R1. In addition, stimulation of TNF-R2 and CD40 synergistically enhances TNF-R1-induced cytotoxicity. These findings describe a novel pro-apoptotic mechanism induced by some members of the TNF-R family.
- Subjects
CELL death; TUMOR necrosis factors; APOPTOSIS; CELL receptors; CELLULAR immunity; LIGANDS (Biochemistry); PROTEOLYTIC enzymes; MOLECULAR biology
- Publication
EMBO Journal, 1999, Vol 18, Issue 11, p3034
- ISSN
0261-4189
- Publication type
Article
- DOI
10.1093/emboj/18.11.3034