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- Title
Enterovirus Infection and Type 1 Diabetes: Closing in on a Link?
- Authors
Rodriguez-Calvo, Teresa; von Herrath, Matthias G.
- Abstract
The article discusses research by L. Krogvold and colleagues that examined the presence of enterovirus infection in patients with type 1 diabetes. Topics mentioned include the presence of the enteroviral capsid protein and hyperexpression of major histocompatibility complex in the islets of the patients, the selective loss of beta-cells, the infiltration of autoreactive CD8 T lymphocytes, and pathological changes in immunology and metabolism of patients with type one diabetes.
- Subjects
ENTEROVIRUS diseases; TYPE 1 diabetes; VIRAL proteins; MAJOR histocompatibility complex; ISLANDS of Langerhans
- Publication
Diabetes, 2015, Vol 64, Issue 5, p1503
- ISSN
0012-1797
- Publication type
Opinion
- DOI
10.2337/db14-1931