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- Title
Glycemic Excursions Throughout the Day Revealed by Continuous Glucose Monitoring in Subjects with Normal Glucose Tolerance and Type 2 Diabetes Mellitus.
- Authors
Yu, Ming; Zhou, Jian; Jia, Weiping; Li, Ming; Lu, Wei; Xiang, Kunsan
- Abstract
Monitoring of glycemic status is considered a cornerstone of diabetes care. Continuous glycemic monitoring provides much more information about shifting glycemic levels throughout the day. In this study, continuous glucose monitoring system (CGMS) was used to further investigate the characteristics of glycemic excursions in subjects with normal glucose tolerance (NGT) and type 2 diabetes mellitus (T2DM). The glycemic profiles in 43 NGT individuals (22 M/21F, 42±12 yrs) and 69 newly diagnosed T2DM patients (43M/26F, 53±13 yrs) without previous management were measured by the CGMS for 71±10 h. The CGMS took a glucose measurement every 5 minutes for a total of 288 measurements every 24 hours. T2DM group in comparison with NGT group exhibited significantly higher values of the diumal glycemic peaks, the differences between maximal and minimal glycemic values (Max-Min), the standard deviation (SD) of the diurnal glycemic excursions and the area under curve (AUC) of glycemia (Shown in table). AUC in 69 diabetic patients was positively correlated with Hb A1c (r=0.81, P < 0.001). After treatment for 2∼3 weeks, Max-Min, SD and AUC with glycemic level above 100 mg/dl were significantly lowered in 23 patients reexamined by the CGMS (from 212.9±57.6 to 126.2±34.7 mg/dl, from 51.3±15.8 to 29.0±11.2 mg/dl and from 125.2±47.6 to 32.3±14.3mg/dl⋅24h, respectively; all P < 0.001). This study indicates that continuous glycemic monitoring offers advantages to revealing more details about the glycemic excursions throughout the day in subjects with NGT and T2DM. The glycemic profiles from the CGMS have a valuable role in identifying the characteristics of glycemic excursions, making the optimal treatment decisions and assessing the efficacy of therapy in T2DM.
- Subjects
BLOOD sugar monitoring; TYPE 2 diabetes; BLOOD sugar; DIABETES; PEOPLE with diabetes
- Publication
Diabetes, 2007, Vol 56, pA111
- ISSN
0012-1797
- Publication type
Article