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- Title
A Putative Role for TRPC6 in Immune-Mediated Kidney Injury.
- Authors
't Hart, Daan C.; van der Vlag, Johan; Nijenhuis, Tom
- Abstract
Excessive activation of the immune system is the cause of a wide variety of renal diseases. However, the pathogenic mechanisms underlying the aberrant activation of the immune system in the kidneys often remain unknown. TRPC6, a member of the Ca2+-permeant family of TRPC channels, is important in glomerular epithelial cells or podocytes for the process of glomerular filtration. In addition, TRPC6 plays a crucial role in the development of kidney injuries by inducing podocyte injury. However, an increasing number of studies suggest that TRPC6 is also responsible for tightly regulating the immune cell functions. It remains elusive whether the role of TRPC6 in the immune system and the pathogenesis of renal inflammation are intertwined. In this review, we present an overview of the current knowledge of how TRPC6 coordinates the immune cell functions and propose the hypothesis that TRPC6 might play a pivotal role in the development of kidney injury via its role in the immune system.
- Subjects
KIDNEY injuries; IMMUNE system; CELL physiology; EPITHELIAL cells; KIDNEY diseases; DIABETIC nephropathies
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 22, p16419
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms242216419