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- Title
A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams.
- Authors
Aksenov, Alexander V.; Aksenov, Dmitrii A.; Kurenkov, Igor A.; Leontiev, Alexander V.; Aksenov, Nicolai A.
- Abstract
The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry.
- Subjects
ORGANIC synthesis; ADDITION reactions; CHALCONES
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 12, p10213
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241210213