We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Mitoregulin Contributes to Creatine Shuttling and Cardiolipin Protection in Mice Muscle.
- Authors
Averina, Olga A.; Permyakov, Oleg A.; Emelianova, Mariia A.; Grigoryeva, Olga O.; Lovat, Maxim L.; Egorova, Anna E.; Grinchenko, Andrei V.; Kumeiko, Vadim V.; Marey, Maria V.; Manskikh, Vasily N.; Dontsova, Olga A.; Vysokikh, Mikhail Yu.; Sergiev, Petr V.
- Abstract
Small peptides compose a large share of the mitochondrial proteome. Mitoregulin (Mtln) is a mitochondrial peptide known to contribute to the respiratory complex I functioning and other processes in mitochondria. In our previous studies, we demonstrated that Mtln knockout mice develop obesity and accumulate triglycerides and other oxidation substrates in serum, concomitant with an exhaustion of tricarboxylic acids cycle intermediates. Here we examined the functional role of Mtln in skeletal muscles, one of the major energy consuming tissues. We observed reduced muscle strength for Mtln knockout mice. Decrease of the mitochondrial cardiolipin and concomitant increase in monolysocardiolipin concentration upon Mtln inactivation is likely to be a consequence of imbalance between oxidative damage and remodeling of cardiolipin. It is accompanied by the mitochondrial creatine kinase octamer dissociation and suboptimal respiratory chain performance in Mtln knockout mice.
- Subjects
CARDIOLIPIN; KREBS cycle; CREATINE kinase; KNOCKOUT mice; FATIGUE (Physiology)
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 8, p7589
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24087589