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- Title
A Narrative Review: Gingival Stem Cells as a Limitless Reservoir for Regenerative Medicine.
- Authors
Fonticoli, Luigia; Della Rocca, Ylenia; Rajan, Thangavelu Soundara; Murmura, Giovanna; Trubiani, Oriana; Oliva, Stefano; Pizzicannella, Jacopo; Marconi, Guya Diletta; Diomede, Francesca
- Abstract
The gingival tissue can be collected in an easy way and represent an accessible source to isolate gingival-derived mesenchymal stem cells (GMSCs). GMSCs are a subpopulation of dental-derived mesenchymal stem cells that show the mesenchymal stem cells (MSCs) features, such as differentiation abilities and immunomodulatory properties. Dental-derived stem cells are also expandable in vitro with genomic stability and the possibility to maintain the stemness properties over a prolonged period of passages. Moreover, several preclinical studies have documented that the extracellular vesicles (EVs) released from GMSCs possess similar biological functions and therapeutic effects. The EVs may represent a promising tool in the cell-free regenerative therapy approach. The present review paper summarized the GMSCs, their multi-lineage differentiation capacities, immunomodulatory features, and the potential use in the treatment of several diseases in order to stimulate tissue regeneration. GMSCs should be considered a good stem cell source for potential applications in tissue engineering and regenerative dentistry.
- Subjects
REGENERATIVE medicine; STEM cells; MESENCHYMAL stem cells; GINGIVA; STEM cell niches; EXTRACELLULAR vesicles
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 8, p4135
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23084135