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- Title
Kurarinone Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting TGF-β Signaling Pathways.
- Authors
Park, Soo-Jin; Kim, Tae-hyoun; Lee, Kiram; Kang, Min-Ah; Jang, Hyun-Jae; Ryu, Hyung-Won; Oh, Sei-Ryang; Lee, Hyun-Jun
- Abstract
Idiopathic pulmonary fibrosis (IPF) is a refractory interstitial lung disease for which there is no effective treatment. Although the pathogenesis of IPF is not fully understood, TGF-β and epithelial–mesenchymal transition (EMT) have been shown to be involved in the fibrotic changes of lung tissues. Kurarinone is a prenylated flavonoid isolated from Sophora Flavescens with antioxidant and anti-inflammatory properties. In this study, we investigated the effect of kurarinone on pulmonary fibrosis. Kurarinone suppressed the TGF-β-induced EMT of lung epithelial cells. To assess the therapeutic effects of kurarinone in bleomycin (BLM)-induced pulmonary fibrosis, mice were treated with kurarinone daily for 2 weeks starting 7 days after BLM instillation. Oral administration of kurarinone attenuated the fibrotic changes of lung tissues, including accumulation of collagen and improved mechanical pulmonary functions. Mechanistically, kurarinone suppressed phosphorylation of Smad2/3 and AKT induced by TGF-β1 in lung epithelial cells, as well as in lung tissues treated with BLM. Taken together, these results suggest that kurarinone has a therapeutic effect on pulmonary fibrosis via suppressing TGF-β signaling pathways and may be a novel drug candidate for pulmonary fibrosis.
- Subjects
PULMONARY fibrosis; IDIOPATHIC pulmonary fibrosis; INTERSTITIAL lung diseases; LUNGS; EPITHELIAL-mesenchymal transition
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 16, p8388
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22168388