We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
High-Fat Diets with Differential Fatty Acids Induce Obesity and Perturb Gut Microbiota in Honey Bee.
- Authors
Wang, Xiaofei; Zhong, Zhaopeng; Chen, Xiangyin; Hong, Ziyun; Lin, Weimin; Mu, Xiaohuan; Hu, Xiaosong; Zheng, Hao
- Abstract
HFD (high-fat diet) induces obesity and metabolic disorders, which is associated with the alteration in gut microbiota profiles. However, the underlying molecular mechanisms of the processes are poorly understood. In this study, we used the simple model organism honey bee to explore how different amounts and types of dietary fats affect the host metabolism and the gut microbiota. Excess dietary fat, especially palm oil, elicited higher weight gain, lower survival rates, hyperglycemic, and fat accumulation in honey bees. However, microbiota-free honey bees reared on high-fat diets did not significantly change their phenotypes. Different fatty acid compositions in palm and soybean oil altered the lipid profiles of the honey bee body. Remarkably, dietary fats regulated lipid metabolism and immune-related gene expression at the transcriptional level. Gene set enrichment analysis showed that biological processes, including transcription factors, insulin secretion, and Toll and Imd signaling pathways, were significantly different in the gut of bees on different dietary fats. Moreover, a high-fat diet increased the relative abundance of Gilliamella, while the level of Bartonella was significantly decreased in palm oil groups. This study establishes a novel honey bee model of studying the crosstalk between dietary fat, gut microbiota, and host metabolism.
- Subjects
HONEYBEES; GUT microbiome; HIGH-fat diet; LIPID metabolism; FATTY acids; PALM oil; SOY oil
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 2, p834
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22020834