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- Title
Molecular Mechanisms of Host Cytoskeletal Rearrangements by Shigella Invasins.
- Authors
Jun Hyuck Lee; HaJeung Park; Yong Ho Park
- Abstract
Pathogen-induced reorganization of the host cell cytoskeleton is a common strategy utilized in host cell invasion by many facultative intracellular bacteria, such as Shigella, Listeria, enteroinvasive E. coli and Salmonella. Shigella is an enteroinvasive intracellular pathogen that preferentially infects human epithelial cells and causes bacillary dysentery. Invasion of Shigella into intestinal epithelial cells requires extensive remodeling of the actin cytoskeleton with the aid of pathogenic effector proteins injected into the host cell by the activity of the type III secretion system. These so-called Shigella invasins, including IpaA, IpaC, IpgB1, IpgB2 and IpgD, modulate the actin-regulatory system in a concerted manner to guarantee efficient entry of the bacteria into host cells.
- Subjects
SHIGELLA; CYTOSKELETAL proteins; MOLECULAR microbiology; MICROBIAL invasiveness; EPITHELIAL cells; HOST-parasite relationships
- Publication
International Journal of Molecular Sciences, 2014, Vol 15, Issue 10, p18253
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms151018253