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- Title
Robust Uptake of Magnetic Nanoparticles (MNPs) by Central Nervous System (CNS) Microglia: Implications for Particle Uptake in Mixed Neural Cell Populations.
- Authors
Pickard, Mark R.; Chari, Divya M.
- Abstract
Magnetic nanoparticles (MNPs) are important contrast agents used to monitor a range of neuropathological processes; microglial cells significantly contribute to MNP uptake in sites of pathology. Microglial activation occurs following most CNS pathologies but it is not known if such activation alters MNP uptake, intracellular processing and toxicity. We assessed these parameters in microglial cultures with and without experimental 'activation'. Microglia showed rapid and extensive MNP uptake under basal conditions with no changes found following activation; significant microglial toxicity was observed at higher particle concentrations. Based on our findings, we suggest that avid MNP uptake by endogenous CNS microglia could significantly limit uptake by other cellular subtypes in mixed neural cell populations.
- Subjects
NANOPARTICLES; CENTRAL nervous system; PATHOLOGY; INTRACELLULAR pathogens; MICROGLIA; PARTICLES; NEURONS; CELL proliferation; TOXICITY testing
- Publication
International Journal of Molecular Sciences, 2010, Vol 11, Issue 3, p967
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms11030967