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- Title
Effects of Hypericum Perforatum, in a rodent model of periodontitis.
- Authors
Paterniti, Irene; Briguglio, Enrico; Mazzon, Emanuela; Galuppo, Maria; Oteri, Giacomo; Cordasco, Giancarlo; Cuzzocrea, Salvatore
- Abstract
Background: Hypericum perforatum is a medicinal plant species containing many polyphenolic compounds, namely flavonoids and phenolic acids. In this study we evaluate the effect of Hypericum perforatum in animal model of periodontitis. Methods: Periodontitis was induced in adult male Sprague-Dawley rats by placing a nylon thread ligature around the lower 1st molars. Hypericum perforatum was administered at the dose of 2 mg/kg os, daily for eight days. At day 8, the gingivomucosal tissue encircling the mandibular first molar was removed. Results: Periodontitis in rats resulted in an inflammatory process characterized by edema, neutrophil infiltration and cytokine production that was followed by the recruitment of other inflammatory cells, production of a range of inflammatory mediators such as NF-κB and iNOS expression, the nitration of tyrosine residues and activation of the nuclear enzyme poly (ADP-ribose) polymerase; apoptosis and the degree of gingivomucosal tissues injury. We report here that Hypericum perforatum exerts potent anti-inflammatory effects significantly reducing all of the parameters of inflammation as described above. Conclusions: Taken together, our results clearly demonstrate that treatment with Hypericum reduces the development of inflammation and tissue injury, events associated with periodontitis.
- Subjects
HYPERICUM perforatum; FLAVONOIDS; PERIODONTITIS; LABORATORY rats; TISSUE wounds
- Publication
BMC Complementary & Alternative Medicine, 2010, Vol 10, p73
- ISSN
1472-6882
- Publication type
Article
- DOI
10.1186/1472-6882-10-73