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- Title
The assessment of hyposalivation and its impact on mouth disability in systemic sclerosis patients.
- Authors
Guler, Aslihan Avanoglu; Karadeniz, Hazan; Bilici, Reyhan; Satış, Hasan; Babaoğlu, Hakan; Ataş, Nuh; Küçük, Hamit; Göker, Berna; Haznedaroğlu, Seminur; Öztürk, Mehmet Akif; Tufan, Abdurrahman
- Abstract
Objective: This study aimed to evaluate the reduction in salivary flow rate (SFR) and the effect of hyposalivation on mouth disability of SSc patients and to the relationship between Sjogren's syndrome (SS) related, SSc-related autoantibodies and hyposalivation in SSc patients Methods: SSc patients who fulfilled American College of Rheumatology/European Alliance of Associations for Rheumatology 2013 criteria of SSc, were included in this cross-sectional study. Unstimulated whole SFR (UWSFR) was performed for the sialometric assessment. The mouth handicap in SSc (MHISS) scale was used for the evaluation of mouth disability. Results: Seventy-two SSc patients (91.7% female) were included in the study. The mean age of patients was 52.2±13 years with 65.3% limited cutaneous SSc (lcSSc). Subjective xerostomia was presented in 44% of patients and reduced UWSFR (=0.1 mL/min) was detected in 39% of patients. A significant difference was not displayed in terms of the presence of xerostomia and hyposalivation between lcSSc and diffuse cutaneous SSc (dcSSc) patients. Patients with hyposalivation had significantly higher MHISS total and subscale 2 scores compared to patients with normal SFR (p=0.04 and p=0.01, respectively). Decreased saliva production was related to the presence of dysphagia [odds ratio (OR): 2.86, 95% confidence interval (CI): 1.01-8.13; p=0.045], anti-Ro60/SSA autoantibody (OR: 3.7, 95% CI: 1.08-12.55; p=0.036), xerophthalmia symptom (OR: 4.3, 95% CI: 1.56-11.77; p=0.005), positive Schirmer's test (OR: 20.7, 95% CI: 6.02-71.08; p<0.001), higher MHISS total (OR: 1.05, 95% CI: 1.00-1.09; p=0.043), and higher MHISS domain 2 scores (OR: 1.13, 95% CI: 1.02-1.24; p=0.02). Conclusion: Hyposalivation and xerostomia are commonly observed in SSc. Patients with hyposalivation had significantly higher mouth disability. The risk factors for hyposalivation in SSc were the presence of anti-Ro60/SSA autoantibody, dysphagia, subjective and objective xerophthalmia, higher MHISS total, and higher MHISS domain 2 scores.
- Subjects
XEROSTOMIA; MULTIPLE sclerosis; RHEUMATOLOGY; AUTOANTIBODIES; DEGLUTITION disorders
- Publication
Journal of Turkish Society for Rheumatology, 2023, Vol 15, Issue 2, p82
- ISSN
2651-2653
- Publication type
Article
- DOI
10.4274/raed.galenos.2023.03511