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- Title
Copper at the Front Line of the Host-Pathogen Battle.
- Authors
Festa, Richard A.; Thiele, Dennis J.
- Abstract
The article discusses the role of copper in microbial pathogenesis. The transition metal functions as a cofactor for enzymes due to its ability to redox cycle between reduced and oxidized forms, but it can also lead to oxidative stress and disrupt iron-sulfur clusters and displace other metals from their cognate enzymes, leading to inactivation. Information on how fungi use and resist copper is provided.
- Subjects
COPPER; BACTERIA; TRANSITION metals; ENZYMES; OXIDATIVE stress; OXIDATION-reduction reaction; FUNGI
- Publication
PLoS Pathogens, 2012, Vol 8, Issue 9, p1
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.1002887