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- Title
Cytotoxic 5-Hydroxyindole Alkaloids from the Marine Sponge Scalarispongia sp.
- Authors
Lee, Yeon ‐ Ju; Lee, Dong ‐ Geun; Rho, Hyun Soo; Krasokhin, Vladimir B.; Shin, Hee Jae; Lee, Jong Seok; Lee, Hyi ‐ Seung
- Abstract
Three new 5-hydroxyindole alkaloids ( 1, 2, 3) along with seven known analogs ( 4, 5, 6, 7, 8, 9, 10) were isolated from a Dokdo marine sponge Scalarispongia sp. The elucidation of the structures of the new compounds by spectroscopic analyses indicated that these compounds were an indole glyoxylate ( 1), a mono-indole analog of hyrtinadine A ( 2), and a symmetrical bis-indole with pyridine linker ( 3). The comparison of IC50 values for obtained compounds against a human leukemia cell line revealed that the bis-indole structure is a requirement for cytotoxicity.
- Subjects
INDOLE compounds; SPONGES (Invertebrates); CHEMICAL structure; PYRIDINE; CELL-mediated cytotoxicity; CANCER cells
- Publication
Journal of Heterocyclic Chemistry, 2013, Vol 50, Issue 6, p1400
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1599