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- Title
Inside Cover: The Synthesis of Highly Active Iridium(I) Complexes and their Application in Catalytic Hydrogen Isotope Exchange (Adv. Synth. Catal. 17/2014).
- Authors
Brown, Jack A.; Cochrane, Alison R.; Irvine, Stephanie; Kerr, William J.; Mondal, Bhaskar; Parkinson, John A.; Paterson, Laura C.; Reid, Marc; Tuttle, Tell; Andersson, Shalini; Nilsson, Göran N.
- Abstract
The inside cover picture, by Kerr and co ‐ workers, depicts a series of robust, yet highly active Ir(I) complexes bearing specifically encumbered N ‐ heterocyclic carbene and phosphine ligands. These complexes are extremely effective in hydrogen isotope exchange processes (with D or T), with low catalyst loadings, good levels of selectivity, and broad directing group applicability. The labelling of several complex drug molecules further highlights the catalysts utility. Mechanistic insight into the operation of these catalysts has also been provided by a combination of NMR and theoretical DFT studies. Details of this work can be found in the full paper on pages 3551 – 3562 (J. A. Brown, A. R. Cochrane, S. Irvine, W. J. Kerr, B. Mondal, J. A. Parkinson, L. C. Paterson, M. Reid, T. Tuttle, S. Andersson, G. N. Nilsson, Adv. Synth. Catal. 2014, 356, 3551 – 3562; DOI:10.1002/adsc.201400730).
- Subjects
CHEMICAL synthesis; CATALYSIS
- Publication
Advanced Synthesis & Catalysis, 2014, Vol 356, Issue 17, p3474
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201401054