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- Title
Hydroxyapatite-alendronate composite systems for biocompatible materials.
- Authors
Neamtu, Johny; Bubulica, Maria; Rotaru, Andrei; Ducu, Catalin; Balosache, Oana; Manda, Valentin; Turcu-Stiolica, Adina; Nicolicescu, Claudiu; Melinte, Razvan; Popescu, Mariana; Croitoru, Octavian
- Abstract
In this study, hydroxyapatite-alendronate composites were synthesized from calcium nitrate, diammonium hydrogen phosphate and alendronate by chemical precipitation method. The obtained materials were analysed by physical-chemical methods, while the compositional and structural characteristics of hydroxyapatite-alendronate phases were determined by a combination of crystallographic, spectroscopic and thermal analysis investigations; moreover, the alendronate content, its maximal incorporation efficiency to hydroxyapatite and stability were determined. A two-level full factorial design was chosen to determine the optimum set of process parameters (synthesis temperature, reactant addition rate and ripening time) and their effects on various hydroxyapatite-alendronate characteristics: alendronate incorporation efficiency, hydroxyapatite crystallite size (XRD), hydroxyapatite particle size distribution (DLS). These effects were quantified using design of experiments. The in vitro release profile of alendronate from hydroxyapatite-alendronate tablets was assessed.
- Subjects
HYDROXYAPATITE; ALENDRONATE; BIOMEDICAL materials; CALCIUM nitrate; PARTICLE size distribution
- Publication
Journal of Thermal Analysis & Calorimetry, 2017, Vol 127, Issue 2, p1567
- ISSN
1388-6150
- Publication type
Article
- DOI
10.1007/s10973-016-5905-9