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- Title
Molecular imaging of pediatric brain tumors: comparison of tumor metabolism using F-FDG-PET and MRSI.
- Authors
Hipp, Sean; Steffen-Smith, Emilie; Patronas, Nicholas; Herscovitch, Peter; Solomon, Jeffrey; Bent, Robyn; Steinberg, Seth; Warren, Katherine
- Abstract
Magnetic resonance spectroscopic imaging (MRSI) and F-fluorodeoxyglucose positron emission tomography (FDG-PET) are non-invasive imaging techniques routinely used to evaluate tumor malignancy in adults with brain tumors. We compared the metabolic activity of pediatric brain tumors using FDG-PET and MRSI. Children ( n = 37) diagnosed with a primary brain tumor underwent FDG-PET and MRSI within two weeks of each other. Tumor metabolism was classified as inactive, active or highly active using the maximum choline: N-acetyl-asparate (Cho:NAA) on MRSI and the highest tumor uptake on FDG-PET. A voxel-wise comparison was used to evaluate the area with the greatest abnormal metabolism. Agreement between methods was assessed using the percent agreement and the kappa statistic (κ). Pediatric brain tumors were metabolically heterogeneous on FDG-PET and MRSI studies. Active tumor metabolism was observed more frequently using MRSI compared to FDG-PET, and agreement in tumor classification was weak (κ = 0.16, p = 0.12), with 42 % agreement (95 % CI = 25-61 %). Voxel-wise comparison for identifying the area of greatest metabolic activity showed overlap in the majority (62 %) of studies, though exact agreement between techniques was low (29.4 %, 95 % CI = 15.1-47.5 %). These results indicate that FDG-PET and MRSI detect similar but not always identical regions of tumor activity, and there is little agreement in the degree of tumor metabolic activity between the two techniques.
- Subjects
BRAIN tumors; TUMORS in children; MOLECULAR diagnosis; POSITRON emission tomography; MAGNETIC resonance imaging of the brain; RADIOPHARMACEUTICALS; NONINVASIVE diagnostic tests
- Publication
Journal of Neuro-Oncology, 2012, Vol 109, Issue 3, p521
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-012-0918-0